(S)-(+)-3-Hydroxytetrahydrofuran

Uses: The synthesis of the anti-AIDS drug amprenavir requires two important intermediates, one of which is (S)-(+)-3-hydroxy Chemicalbook Tetrahydrofuran. It can be synthesized by asymmetric borohydride or hydrosilation of dihydrofuran, asymmetric hydrogenation reduction of 4-chloro 3-carbonyl butyrate-intramolecular etherification, enzymatic resolution of 3-hydroxytetrahydrofuran racemate, etc. But in most cases the optical purity of the product is not enough. (S)-(+)-3-Hydroxytetrahydrofuran can be used for the first-line treatment of advanced non-small cell lung cancer (NSCLC) and the intermediate of the API afatinib for patients with HER2-positive advanced breast cancer. It is an intermediate of afatinib .